{"id":142,"date":"2025-09-01T08:23:02","date_gmt":"2025-09-01T08:23:02","guid":{"rendered":"https:\/\/shining-biotech.breadnbutteryilan.com\/?page_id=142"},"modified":"2026-04-29T10:34:42","modified_gmt":"2026-04-29T02:34:42","slug":"wt-1-%e7%99%8c%e7%97%87%e7%96%ab%e8%8b%97","status":"publish","type":"page","link":"https:\/\/staging.shining-biotech.com\/ja\/wt-1-%e7%99%8c%e7%97%87%e7%96%ab%e8%8b%97\/","title":{"rendered":"WT-1\u304c\u3093\u30ef\u30af\u30c1\u30f3"},"content":{"rendered":"
\n
\"\"<\/figure>\n\n\n\n

WT-1\u304c\u3093\u30ef\u30af\u30c1\u30f3<\/h2>\n<\/div>\n\n\n\n
\n
\n
\n
\n
\n
WT-1\u304c\u3093\u30ef\u30af\u30c1\u30f3<\/strong><\/h6>\n\n\n\n
\u751f\u4f53\u306e\u514d\u75ab\u7cfb\u306f\u3001\u300c\u975e\u81ea\u5df1\u300d\u3068\u300c\u81ea\u5df1\u300d\u3092\u8b58\u5225\u3059\u308b\u7570\u306a\u308b\u7279\u5fb4\u3092\u8a8d\u8b58\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u9632\u5fa1\u6a5f\u69cb\u3092\u6d3b\u6027\u5316\u3057\u3001\u304c\u3093\u7d30\u80de\u3084\u5916\u6765\u6027\u75c5\u539f\u4f53\u3092\u6392\u9664\u3059\u308b\u3002\u514d\u75ab\u7cfb\u306b\u304a\u3051\u308b\u6a39\u72b6\u7d30\u80de\uff08dendritic cell, DC\uff09\u306e\u5f79\u5272\u306f\u3001\u8ecd\u968a\u306b\u304a\u3051\u308b\u6559\u5b98\u306b\u4f8b\u3048\u3089\u308c\u308b\u3002\u6a39\u72b6\u7d30\u80de\u306f\u3001\u304c\u3093\u7d30\u80de\u3084\u75c5\u539f\u4f53\u304b\u3089\u653e\u51fa\u3055\u308c\u308b\u6297\u539f\u3092\u5229\u7528\u3057\u3066\u3001\u672a\u6d3b\u6027\u5316T\u7d30\u80de\u3092\u6559\u80b2\u3059\u308b\u3002\u307e\u305f\u3001\u6a39\u72b6\u7d30\u80de\u306f\u514d\u75ab\u7cfb\u306b\u304a\u3044\u3066\u6700\u3082\u9ad8\u3044\u6297\u539f\u63d0\u793a\u80fd\u3092\u6709\u3059\u308b\u7d30\u80de\u306e\u4e00\u3064\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u3066\u3044\u308b\u3002\u6a39\u72b6\u7d30\u80de\u306fT\u7d30\u80de\u306e\u6d3b\u6027\u5316\u304a\u3088\u3073\u5897\u6b96\u3092\u8a98\u5c0e\u3057\u3001\u304c\u3093\u7d30\u80de\u307e\u305f\u306f\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u7d30\u80de\u3092\u7279\u7570\u7684\u306b\u8a8d\u8b58\u3059\u308b\u5927\u91cf\u306eT\u7d30\u80de\u3092\u7523\u751f\u3059\u308b\u30021<\/a><\/span>\u3002
2009\u5e74\u306b\u7c73\u56fd\u56fd\u7acb\u304c\u3093\u7814\u7a76\u6240\uff08National Cancer Institute, NCI\uff09\u304c\u5b9f\u65bd\u3057\u305f\u89e3\u6790\u304a\u3088\u3073\u6bd4\u8f03\u691c\u8a0e\u306b\u3088\u308b\u3068\u3001Wilms\u2019<\/span>2009\u5e74\u306b\u7c73\u56fd\u56fd\u7acb\u304c\u3093\u7814\u7a76\u6240\uff08National Cancer Institute, NCI\uff09\u304c\u5b9f\u65bd\u3057\u305f\u89e3\u6790\u304a\u3088\u3073\u6bd4\u8f03\u691c\u8a0e\u306b\u3088\u308b\u3068\u3001Wilms tumor 1\uff08WT1\uff09\u306f\u6700\u3082\u6709\u671b\u306a\u816b\u760d\u6297\u539f\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u591a\u69d8\u306a\u56fa\u5f62\u816b\u760d\u304a\u3088\u3073\u767d\u8840\u75c5\u306b\u304a\u3044\u3066\u9ad8\u767a\u73fe\u3092\u793a\u3059\u30022,<\/a>3<\/a>\u3002<\/span>\u65e5\u672cTIMO\u304c\u958b\u767a\u3057\u305f WT1\u304c\u3093\u30ef\u30af\u30c1\u30f3\u306f\u3001\u5e83\u7bc4\u306a\u6297\u816b\u760d\u52b9\u679c\u3092\u6709\u3059\u308b\u9ad8\u52b9\u7387\u306a\u304c\u3093\u30ef\u30af\u30c1\u30f3\u3067\u3042\u308a\u3001\u6700\u592795\uff05\u306e\u304c\u3093\u7a2e\u306b\u304a\u3051\u308b\u304c\u3093\u7d30\u80de\u306e\u5909\u5316\u306b\u5bfe\u3057\u3066\u3001\u6709\u52b9\u306a\u4e88\u9632\u304a\u3088\u3073\u6cbb\u7642\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3002<\/strong>WT1\u30ef\u30af\u30c1\u30f3\u306e\u63a5\u7a2e\u5f8c\u3001\u7279\u6b8a\u306a\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u306b\u3088\u308a\u30ef\u30af\u30c1\u30f3\u6210\u5206\u304c\u5f90\u653e\u3055\u308c\u3001\u6a39\u72b6\u7d30\u80de\uff08dendritic cell, DC\uff09\u306b\u3088\u308b\u30ef\u30af\u30c1\u30f3\u4e2d\u306e\u30da\u30d7\u30c1\u30c9\u306e\u53d6\u308a\u8fbc\u307f\u304a\u3088\u3073\u6297\u539f\u63d0\u793a\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u7d30\u80de\u3092\u7279\u7570\u7684\u306b\u8a8d\u8b58\u3059\u308b\u30e1\u30e2\u30ea\u30fcT\u7d30\u80de\uff08memory T cell\uff09\u306e\u8a98\u5c0e\u30fb\u5897\u5e45\u3092\u4fc3\u9032\u3057\u3001\u52b9\u679c\u7684\u306a\u304c\u3093\u6cbb\u7642\u3001\u3055\u3089\u306b\u306f\u751f\u6daf\u306b\u308f\u305f\u308b\u304c\u3093\u4e88\u9632\u514d\u75ab\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3059\u3002\u4e0b\u56f3\u306b\u793a\u3059\u3088\u3046\u306b\u3001\u7c73\u56fd\u56fd\u7acb\u304c\u3093\u7814\u7a76\u6240\uff08National Cancer Institute, NCI\uff09\u306f75\u7a2e\u985e\u306e\u816b\u760d\u6297\u539f\u306b\u3064\u3044\u3066\u89e3\u6790\u304a\u3088\u3073\u6bd4\u8f03\u691c\u8a0e\u3092\u884c\u3044\u3001\u6cbb\u7642\u6709\u52b9\u6027\u3001\u514d\u75ab\u539f\u6027\uff08immunogenicity\uff1a\u514d\u75ab\u5fdc\u7b54\u3092\u8a98\u5c0e\u3059\u308b\u80fd\u529b\uff09\u3001\u7279\u7570\u6027\u3001\u816b\u760d\u539f\u6027\uff08oncogenicity\uff09\u306a\u3069\u306e\u7406\u60f3\u7684\u306a\u304c\u3093\u6297\u539f\u3068\u3057\u3066\u306e\u8a55\u4fa1\u57fa\u6e96\u3092\u7dcf\u5408\u7684\u306b\u6bd4\u8f03\u3057\u305f\u7d50\u679c\u3001WT1\u304c\u6700\u3082\u6709\u671b\u306a\u816b\u760d\u6297\u539f\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u30023<\/a><\/span>\u3002<\/pre>\n\n\n\n
\"\"<\/figure>\n<\/div>\n\n\n\n
\n
\u53c2\u8003\u6587\u732e<\/h6>\n\n\n\n
\n
1. Cross-Talk Between Antigen Presenting Cells and T Cells Impacts Intestinal Homeostasis, Bacterial Infections, and Tumorigenesis<\/h6>\n\n\n\n
Gaudino SJ, et al. Front Immunol. 2019:10:360.<\/pre>\n<\/div>\n\n\n\n
\n
2. Wilms’ tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis<\/h6>\n\n\n\n
Qi XW, et al. Sci Rep. 2015;5:8924<\/p>\n<\/div>\n\n\n\n
\n
3. The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research<\/h6>\n\n\n\n
Cheever MA, et al. Clin Cancer Res. 2009;15:5323-37.<\/pre>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"
WT-1 \u764c\u75c7\u75ab\u82d7 WT-1 \u764c\u75c7\u75ab\u82d7 \u8eab\u9ad4\u7684\u514d\u75ab\u7cfb\u7d71\u8981\u80fd\u8fa8\u8b58\u300c\u6575\u300d\u8207\u300c\u6211\u300d\u7684\u4e0d\u540c\u7279\u5fb5\uff0c\u624d\u80fd\u5920\u555f\u52d5\u6a5f\u5236\uff0c\u6bba\u6b7b\u764c\u7d30\u80de\u6216\u5916\u4f86\u7684\u75c5\u539f\u9ad4\u3002\u514d\u75ab\u7cfb\u7d71\u4e2d\u6a39\u7a81\u7d30\u80de (dendritic cell, DC) \u7684\u89d2\u8272\uff0c\u5c31\u50cf\u662f\u8ecd\u968a\u88e1\u7684\u6559\u5b98\uff0c […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-142","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/staging.shining-biotech.com\/ja\/wp-json\/wp\/v2\/pages\/142","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.shining-biotech.com\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/staging.shining-biotech.com\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/staging.shining-biotech.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.shining-biotech.com\/ja\/wp-json\/wp\/v2\/comments?post=142"}],"version-history":[{"count":39,"href":"https:\/\/staging.shining-biotech.com\/ja\/wp-json\/wp\/v2\/pages\/142\/revisions"}],"predecessor-version":[{"id":2641,"href":"https:\/\/staging.shining-biotech.com\/ja\/wp-json\/wp\/v2\/pages\/142\/revisions\/2641"}],"wp:attachment":[{"href":"https:\/\/staging.shining-biotech.com\/ja\/wp-json\/wp\/v2\/media?parent=142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}